I'm becoming a huge fan of Hampton Inns, and this one is no different. Decent sized rooms, very reasonable price (around 115/night on the weekend).
Free hot breakfast and free internet. Sits at the top of Route 14, which allows you to hit all of the wineries before the crowds, as the crowds normally start south and go north.
Nice tile floor in the bathrooms, nice amenities (fitness center, pool, hot tub). Good coffee.